01.Jun.2020
Calcium carbonate must be processed before it can be compressed into tablets. This study examined the compression behavior of calcium carbonate powder when granulated with different binders. Hydroxypropyl cellulose (HPC), hydroxypropyl methylcellulose (HPMC) and sodium alginate (Na-Alg), were chosen at different concentrations as binding agents. Data analysis and optimization were carried out using load-displacement curves and the Kawakita model of powder compression. The viscosity of the binder solutions, the specific surface area of the granulated CaCO3 and the contact angle of the binder solutions on CaCO3 compact surfaces were used to interpret granulation behavior. Each binder interacted differently with CaCO3 with respect to powder and tablet properties. Optimum tablet processing was found to be strongly dependent on the compression pressure and concentration of the binder used. A 3% binder concentration gave the most desirable outcomes with respect to the area under the load-displacement curves (AUCs), the Kawakita parameter (Pk ) and tablet crushing strength (TCS). Calcium carbonate tablets prepared at the optimum binder concentration were stable when stored under accelerated stability conditions.https://www.researchgate.net/publication/342215370_Enhancement_of_compression_and_compaction_properties_of_calcium_carbonate_powder_by_granulation_with_HPC_HPMC_and_sodium-_alginate_as_binders_for_pharmaceutical_applications_an_optimization_case_study
Calcium carbonate must be processed before it can be compressed into tablets. This study examined the compression behavior of calcium carbonate powder when granulated with different binders. Hydroxypropyl cellulose (HPC), hydroxypropyl methylcellulose (HPMC) and sodium alginate (Na-Alg), were chosen at different concentrations as binding agents. Data analysis and optimization were carried out using load-displacement curves and the Kawakita model of powder compression. The viscosity of the binder solutions, the specific surface area of the granulated CaCO3 and the contact angle of the binder solutions on CaCO3 compact surfaces were used to interpret granulation behavior. Each binder interacted differently with CaCO3 with respect to powder and tablet properties. Optimum tablet processing was found to be strongly dependent on the compression pressure and concentration of the binder used. A 3% binder concentration gave the most desirable outcomes with respect to the area under the load-displacement curves (AUCs), the Kawakita parameter (Pk ) and tablet crushing strength (TCS). Calcium carbonate tablets prepared at the optimum binder concentration were stable when stored under accelerated stability conditions.
https://www.researchgate.net/publication/342215370_Enhancement_of_compression_and_compaction_properties_of_calcium_carbonate_powder_by_granulation_with_HPC_HPMC_and_sodium-_alginate_as_binders_for_pharmaceutical_applications_an_optimization_case_study
17.Apr.2024
16.Jan.2024
20.Sep.2023
أنا طالبة في الهندسة الصناعية, اختياري لهذا التخصص كان بناءً على أهميته الكبيرة كمهنة في الحاضر والمستقبل ... رغد بركات
الهندسة الصناعية تساعدك على اتخاذ قرارات أفضل، وتعطي أشكالا أخرى من مبادئ الهندسة بشكل عملي وعلمي في آن. ... محمود صلاح
قسم الهندسة الكيميائية قسم جميل جدا تعلمت فيه الكثير ومما تعلمته فيه جدية العمل وروح الفريق الواحد .. ... رغد الشويكي